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Most researchers report initial symptom changes (reduced pain intensity, less burning, improved sensation) within 4 to 8 weeks

Additionally, anxiety and stress trigger SNS hyperactivity, increasing renin release and angiotensin II, which promote renal vasoconstriction and tubulointerstitial damage (Wang and Dong, 2016) while elevated norepinephrine levels under mental distress accelerating kidney function decline (Tidgren and Hjemdahl, 1989)

Up-regulation of glutathione synthesis in rat kidney by methyl mercury