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But in March 2024, the US Food and Drug Administration expanded the indication of the peptide to help obese people lose weight and reduce the risk of cardiovascular incidents

That being said, different mechanisms may offer different side effect profiles, and its possible that future multi-agonists could yield improved tolerability profiles

Jelly Roll revealed on The Joe Rogan Experience podcast in December 2025 that he told his family which includes wife Bunnie XO , daughter Bailee and son Noah that he would start working on losing weight for years before actually following through