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In an in vitro study, tirzepatide elicited a cAMP response in a human pancreatic -cell line that was significantly higher than that observed for either GLP-1 or GIP alone, indicating a synergistic or additive activation of signaling in pancreatic -cells by GIP and GLP-1 (63)

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Its removal from Category 1 means it is moving into the PCAC review pipeline for a definitive determination rather than remaining in the indefinite "under evaluation" holding pattern

Weighing Long-Term Benefits and Risks Long-term benefits and risks are a crucial consideration in expert opinions