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However, by 9 hpt, iron sucrose began to counteract DHAs efficacy: DHA alone reduced parasitemia from 2.11% (control) to 1.67%, whereas cotreatment with iron sucrose increased parasitemia to 1.97%, weakening DHAs inhibitory activity

Among these approaches, the first-generation D+Q combination has accumulated the most experimental data regarding safety and efficacy, and CNS bioavailability (9599)

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