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The free tripeptide chelates a single Cu(II) ion through its N-terminal amine, the deprotonated glycyl amide nitrogen and the histidine imidazole, giving the square-planar complex responsible for the deep blue colour of a reconstituted ghkcu solution

Activated CAFs facilitate tumor cell growth, invasiveness, and drug resistance by depositing extracellular matrix (ECM) and secreting cytokines, chemokines, and growth factors (zdemir et al., 2014)

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