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It is intended to be used alongside diet and physical activity, and one notable difference is that it can be taken with or without food

These include: Nausea (affecting up to 43% of patients at weight management doses) Vomiting (up to 23%) Diarrhoea (up to 30%) Constipation (up to 24%) Abdominal pain or discomfort These effects typically diminish over time as the body adapts, though some patients experience persistent symptoms requiring dose adjustment or discontinuation

The ULK1 phosphorylates activating molecule in Beclin1-regulated autophagy protein 1 (AMBRA1) leading to translocation of Bcl-2-interacting myosin-like coiled-coil protein (Beclin-1) towards the ER

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