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In accordance with this, it has been estimated that the steady-state concentration of superoxide in the mitochondrial matrix is 5- to 10- fold higher than in the cytosol (Cadenas and Davies, 2000)

Clinical Signs I Watch For In Patients New or worse sadness, persistent low mood, or loss of interest in usual activities Increased irritability or emotional numbing Trouble sleeping from racing thoughts or anxiety Appetite is so suppressed that caloric and protein targets are missed Any thoughts of self-harm or suicidal ideation: this needs immediate contact with a clinician or emergency services Could It Be Under-Eating Or Nutrient Problems Rather Than The Drug

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