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While analyses restricted to participants with established cardiovascular disease yielded MACE results that were directionally consistent with the overall analysis, conclusions are limited because subgroup estimates were based on trial-level reporting rather than individual participant data, and included studies continued to differ in patient characteristics, definitions of established cardiovascular disease, background therapies, and trial era

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These changes contribute to the gradual accumulation of cholesterol and subsequent deposition of gallstones

According to what I've read, taurine and beta-alanine compete for the same receptors in the body, so supplementing with beta-alanine could result in a taurine deficiency