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For such cases, a comprehensive assessment integrating primary tumor location, metastatic pathway, and multimodal diagnostic toolssuch as CSF cytology and targeted biopsyis essential to avoid misinterpretation based solely on imaging

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5 Limitations and future directions of research Given the scope of the present study, several key factors warrant acknowledgment: First, bridging the translational gap between animal models and human clinical applications is challenging

In some embodiments, the formulation or composition comprises between about 0.1% to about 50% by weight of the viscosity modulating agent