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coadministration of weight-based RBV is recommended if testing for Y93H is positive.[12] Additionally, the American Association for the Study of Liver Diseases recommends 12 weeks of SOF/VEL plus RBV, regardless of viral resistance testing, for prior pegIFN/RBV treatment-experienced patients with compensated cirrhosis, in part based on a modest increase in SVR12 rate observed with RBV coadministration in patients with cirrhosis and prior IFN-based treatment experience.[15] The European Association for the Study of the Liver recommends that patients with compensated cirrhosis and/or prior treatment experience who test positive for Y93H in nonstructural protein 5A (NS5A) should also have weight-based RBV coadministered with SOF/VEL.[13] Most recently the American Association for the Study of Liver Diseases recommended 12 weeks of glecaprevir/pibrentasvir for treatment-naive patients with GT3 infection and compensated cirrhosis, without the need for viral resistance testing or RBV coadministration
These favorable effects may contribute to the observed survival benefits in patients with type 2 diabetes and concomitant AKD
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S., Ramzan, A., Ali, A., & Ahmad, M
