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Metabolic effects of GLP-1R agonismGIPR antagonism in DIO Per-Gipr KO mice Consistent with previous data showing that GIPR agonism acts in the CNS 15 to decrease food intake via GABAergic GIPR neurons 14 , we found that the inhibition of food intake following single subcutaneous (s.c.) administration of acyl-GIP (100 nmol kg 1 ) was fully preserved in DIO Per-Gipr KO mice (Fig
Additionally, lifestyle factors such as a low-fiber diet, prolonged sitting, or straining during bowel movements can exacerbate these symptoms
F.BolyM.HwangG.NairV.MathisJ.NenckaA.et al
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