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p53 mutations can increase heterogeneity in gene expression, the cell cycle status, and metabolic features within the tumor cell population

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414 Although no specific recommendation has been advanced for vaccination against hepatitis B, the evidence that persons co-infected with hepatitis B and C have a worse prognosis than those with HCV infection alone 415 suggests that hepatitis B vaccination should be offered to persons who are at risk for exposure to hepatitis B if they lack preexisting antibody to hepatitis B

Peptides are usually delivered via subcutaneous injection, which is very similar to how insulin injections help those with diabetes