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Who Should Consider GLP-1 Drugs And Who Shouldn't Good Candidates BMI 30+ (obese) The primary indication for all weight-management GLP-1s BMI 27+ with a weight-related condition (diabetes, high blood pressure, sleep apnea, PCOS, fatty liver) Failed sustained weight loss through diet and exercise alone for 6+ months Pre-diabetic GLP-1s can prevent progression to Type 2 diabetes Cardiovascular risk Semaglutide specifically has proven heart protection Not Appropriate For Cosmetic weight loss of a few kilograms These are serious medications, not diet pills History of medullary thyroid cancer or MEN2 syndrome Absolute contraindication History of pancreatitis Relative contraindication

Side Effects That Matter for Training The side effect profile of GLP-1 medications has specific implications for athletes that differ from the general population

Essential molecule for supporting healthy brain function

The traditional approval also expands Filsparis indication, allowing for its use to slow the decline of kidney function in adult patients who are at risk of disease progressionwhile also removing a previous requirement of having a specific urinary protein level