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The global sensitivity analysis suggests that the comproportionation reaction, R 5 , is not pivotal for the model OCR output, given that its parameters, k p5 and k m5 , are the two least sensitive parameters for both main and total interactions

The MHRA SmPC advises that when tirzepatide is used with insulin or a sulfonylurea, a reduction in the dose of these medications should be considered to reduce the risk of hypoglycaemia

6 The HPLC-TOF-MS spectrum and SEC chromatograph of AMG 133

Baseline thyroid function tests (TSH, free T4) and calcitonin levels may be considered, though routine calcitonin monitoring is debated among endocrinologists