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The underlying molecular mechanism is that tumours driven by BRAF V600E exhibit high extracellular signal-regulated kinase phosphorylation, which activates the mitogen-activated protein kinase (MAPK) signalling pathway, leading to unregulated cell proliferation and a poor prognosis [72]

It is now the most common liver disorder in the Western world, with an incidence rate of over 25% 1,2,3,4

Retatrutide has not received MHRA or EMA marketing authorisation and is only accessible in the UK through regulated clinical trials

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