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4.1 The translational gap between preclinical models and human disease Current insights into the role of ferroptosis in DACD are largely based on evidence from preclinical models, including genetically modified or chemically induced rodents (e.g., db/db mice, STZ-induced rats) and immortalized cell lines (e.g., PC12 cells) ( 4.2 Hurdles in the clinical development of ferroptosis inhibitors Ferroptosis inhibitors, exemplified by Fer-1, have proven effective in preclinical studies

Knowing the risks and benefits helps them work with their doctors

It can cause dysfunction and inflammation, which may lead to pancreatitis

Consult your provider if fatigue is severe, worsening, or does not improve after addressing nutrition and hydration