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In addition, tirzepatide administration reduced the levels of YKL-40 and leptin versus placebo and dulaglutide treatment.37 Tirzepatide treatment at a dose of 15 mg also decreased ICAM-1 levels compared with placebo and dulaglutide administration and reduced high-sensitivity C-reactive protein levels compared with baseline and placebo treatment, but not dulaglutide treatment.37 The mechanism by which tirzepatide reduces these inflammatory markers is not fully understood

The senior author of the paper is HDRF Depression Task Force member Dr

1 H-MRS semi-quantification of liver lipids were performed on a Bruker BioSpec 70/30USR Avance III 7 T horizontal bore MR scanner (Bruker Biospin MRI GmbH, Ettlingen, Germany)