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Preconception washout periods Washout guidance differs by medication: Semaglutide (Ozempic, Wegovy) : discontinue at least 2 months before a planned pregnancy due to its long half-life

Author Contributions D.K

Butyrate is a major source of energy for colon epithelial cells and is one of the anti-inflammatory metabolites that maintains the integrity of mucosal barriers [45,91,92]

In both pathways, cysteine-dependent proteases known as caspases execute apoptotic cell death by cleaving key structural and regulatory proteins, primarily through the action of caspase-3 (CASP3) and caspase-7 (CASP7), with caspase-6 (CASP6) contributing to downstream substrate cleavage and apoptotic progression