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SREBP-2 inhibition by small interfering RNA in GLP-1RAs treated cells amplified the reduction in the expression of HMGCR , SQLE , LXR , CYP7A1 , and PCSK9 genes and HMGCR protein, as well as the increase in expression of the LDLR gene

GHK-Cu, also known by its cosmetic ingredient (INCI) name Copper Tripeptide-1 , is a naturally occurring copper peptide made up of three amino acids bound to a copper ion

Interestingly, while total testosterone may increase with semaglutide use, free testosteronethe form readily available for the body to usecan sometimes decline

Funding: The authors received no specific funding for this work