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Participants receiving combination cagrilintide and semaglutide had a greater reduction in FPG than those receiving cagrilintide (mean change, 59.4 mg/dL vs

Fragmentation, indicative of compromised cytoplasmic integrity, was notably reduced in the 0.1mM Epithalon group, implying a protective action on cellular morphology

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REDEFINE is an ongoing phase 3 trial acting as market evaluation for both CagriSema and cagrilintide, with 60% randomised to CagriSema, 10% cagrilintide, 10% semaglutide, and 20% placebo, where minimum age at inclusion was 55 years with no upper limit [117]