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63 Prolonged skeletal muscle inactivity promotes mitochondrial dysfunction, resulting in increase in mitochondrial ROS production and leading to protracted oxidative stress and disturbed redox signaling, 64 which can exacerbate IR through multiple pathways such as JNK and NF-B pathways (Fig

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The 12 mg trial dose is rarely described in community references because the GI burden was the rate-limiting factor in the trial

) fruit extract with 45% piperine 2 mg (piperine 0,9 mg)