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These varying evidence sources possess distinct bias structures: RCTs provide average efficacy under ideal conditions but often exclude high-risk or complex patients

Complicaciones digestivas graves Pancreatitis aguda : Estudios recientes muestran un riesgo aumentado de esta patologa con estos frmacos (1, 12-14)

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Caution is advised, with dose reduction recommended in some cases, when they are combined with a sulphonylurea or insulin as the risk of hypoglycemia is higher