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A phase 2 trial of triagonist retatrutide, including 338 adults with obesity compared to placebo over 48 weeks, reported a 24.2% average weight reductionthe highest weight loss from a pharmacologic agentand improvements in cardiometabolic parameters, as well as a MASLD sub-study of 98 patients with 90% of participants showing normalisation of liver triglyceride content by magnetic resonance imaging proton density fat fraction (MRI-PDFF) following treatment with the two highest doses of the drug [9395]

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doi: 10.1128/microbiolspec.AID-0022-2014