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Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B

The DHS-led survival advantage of mice was accompanied by an increase in the total GPx activity as well as mRNA expression levels of seleno-GPxs ( GPx1 , GPx2 , GPx3 , and GPx4 ), reduction of lipid peroxidation, and suppression of inflammatory response (decrease of the expressions of pro-inflammatory genes and infiltration of inflammatory cells) in the radiosensitive organs such as spleen, intestine, and lung

This specific property has become the focus of numerous research strategies, such as the development of senolytic agents like FOXO4-DRI, which selectively disrupt the FOXO4p53 interaction, thereby enabling the targeted elimination of dysfunctional cells

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