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GSH dysregulation might cause global immune cell autophagy decline with increased generation of proinflammatory cytokines in aging, further provoked by mitochondrial ROS signaling (293)

The early decline phase (weeks 2-8) marks when users first notice subtle changes as copper levels normalize to dietary intake baseline, collagen synthesis rates decline toward pre-treatment levels, and the balance between new collagen production and ongoing degradation shifts toward net neutral or slight decline

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