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However, it is well-established that both autophagy and proteasomal function decrease with age (Saez and Vilchez, 2014), and autophagy dysfunction in particular has been linked to changes in NSC and HSC ability to exit quiescence and self-renew, respectively (Leeman et al., 2018)

Pernicious anemia is a type of vitamin B12 deficiency anemia, characterized by the bodys inability to absorb vitamin B12 efficiently

Expanding that framework, or developing alternatives that achieve similar outcomes for the commercially insured population, will require policy innovation that moves faster than the current rate of change

Using various biochemical and biophysical approaches, we demonstrate that Syn WT engages in functional interactions, whereas C-terminal acidic tail truncated Syn 1103 and S129-phosphomimicking ( S129E ) mutant are reactive, displaying broad, non-functional aberrant binding and impairing chaperone-mediated refolding