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4.1 Central nervous system effects GLP-1R is distributed throughout various regions in the brain, with the highest concentrations being found in the hippocampus and cerebral cortex, areas mainly responsible for cognitive function, memory improvement, and learning (22), as well as in microglia and astrocytes (23)

they need to be used in combination with other hypoglycemic drugs or insulin, thereby posing a risk of hypoglycemia related to the type of combined drug and dose

Hair thinning is a common, well-documented side effect of GLP-1 medications

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