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It doesnt exclude a whole lot of patients, remembering that the prevalence of medullary thyroid cancer and MEN 2 in the general adult population is somewhere between 1 in 30,000 and 1 in 40,000. Pearce adds that patients and doctors alike should not be unduly concerned by any possible effects on the thyroid

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GLP-1s may not be suitable for people who: Have a history of pancreatitis Have certain thyroid conditions (e.g., medullary thyroid cancer) Are pregnant or breastfeeding (depending on the specific medication) Have severe gastrointestinal conditions, like gastroparesis GLP-1 receptor agonists, including Tirzepatide, have been shown to lead to significant weight loss, with many people losing 10-15% of their body weight over time