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Furthermore, the weight loss effect of GLP-/GIP dual agonists is achieved by combining an increase in energy expenditure with a decrease in food intake [130], and its potential in the treatment of obesity has been validated in clinical trials

Because of that, many providers use it off-label for obesitybut insurance often wont pay if you dont have a diabetes diagnosis

As the accessibility of these medications continues to rise and patient uptake increases, its crucial that we understand the neural mechanisms underlying the effects were seeing, said Lorenzo Leggio, M.D., Ph.D., Clinical Director of NIHs National Institute on Drug Abuse (NIDA)

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