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However, excessive activation of apoptosis-related pathways could be harmful and lead to nerve function defects, resulting in a variety of cognitive dysfunctions, neurobehavioral disturbances, and emotional disorders [97]

Free radicals are unstable atoms that can cause oxidative stress, leading to cellular damage over time

By modulating dopamine pathways in the brain, these medications could help reduce cravings and compulsive behaviours across a spectrum of addictions

Therapeutic strategies aimed at reducing uremic toxin levels, such as the use of intestinal adsorbents or gut microbiota modulators (e.g., probiotics), may help mitigate macrophage-driven vascular inflammation