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Among the seven conserved functional areas referred to as the Nrf2-ECH homology (Neh) domains of Nrf2, Neh1 primarily dimerises and attaches to small Maf (sMAF) proteins before going on to bind to DNA [13, 14]
It is a particular factor during the early phases of treatment and mentioned as something to monitor in cases of severe anaemia in NICE guidelines
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The amylin receptor agonism it produces slows gastric motility specifically during the postprandial window
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