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Phase 2 and 3 studies, such as randomized controlled trials, have shown that these agents significantly reduce liver fat content, improve liver enzyme profiles, and promote histological improvements in patients with MASLD and MASH (6, 46)

Essential for energy metabolism and neurological function

Retatrutide simultaneously activates GLP-1, GIP, and glucagon receptors, producing pronounced effects on weight and blood glucose

This GLP-1 release stimulates the brain to suppress appetite, enhances glucose disposal, and improves insulin sensitivity, contributing to metabolic benefits like reduced food intake, obesity, and better glucose tolerance