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Inhibitors of the MDM2/p53 interaction, such as UBX0101 and RG7112 (RO5045337), and inhibition of the de-ubiquitinating ubiquitin-specific peptidase 7 (USP7) increase and stabilize p53 levels and have been investigated for their senolytic effects

Nitric oxide synthase (NOS) as therapeutic target for asthma and chronic obstructive pulmonary disease

The research found that the popular drug decreased #heartmuscle mass in lean and obese mice as well as in lab-grown human heart cells

3.3 Chrononutrition Circadian misalignment in food intake may also impact metabolic and cardiac health (35), suggesting additional putative links between IF and CVD