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Purinergic Signal

DNA Damage and cellular cleanup DNA damage builds up with age and is linked to diseases and cellular decline

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CpG methylation induces histone deacetylation, chromatin remodeling, and gene silencing through a transcription repressive complex, which includes SMRT (silencing mediators of retinoic acid and thyroid receptor), mSin3a, RbAp46/48, and the formation around mSin3a The two histone deacetylases HDAC1 and HDAC2