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Local Action and Transdermal Absorption Transdermal absorption mechanism: L-carnitine enters the subcutaneous fat layer through pathways such as diffusion through the stratum corneum, penetration through hair follicles and sweat glands

Glutathione may influence skin brightness, elasticity, and hydration, though results across studies are mixed

Interestingly, while inhibition of MEK by PD98059 effectively suppressed ERK1/2 activation, reduced p-ERK1/2 expression levels, and alleviated the EMT process, TB001 did not affect ERK1/2 signaling pathway ( Figure 8E ), aligning with the immunohistochemistry results in kidney grafts