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In comparing treatments for type II diabetes and obesity, 78.3% of diabetes drugs are in advanced stages (Phase III or beyond), while only 53.9% of weight loss drugs have reached these later stages

Researchers have also questioned whether the increase in cognitive or dietary restraint seen with GLP-1RAs reflects healthier control over eating or a more rigid form of food restriction that could prove harmful

22,53 In the LEADER trial, which enrolled 9,340 patients with T2D at high cardiovascular risk, liraglutide demonstrated modest reduction in systolic BP (mean difference: 1.2 mm Hg

Delayed stomach emptying followed by accelerated colon transit is a problematic mismatch, which can directly lead to diarrhea