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A 2025 meta-analysis by South Valley University found a similar pattern when it pooled the Yale trial with 2 others

Lankisch, P

This timing recommendation is based on the medication's short-acting profile and its mechanism of slowing gastric emptying, which is most beneficial when timed with food intake

A clinical study involving 564 adults (BMI 30-40 kg/m2, without T2DM) found that compared with orlistat (3120 mg, weight loss of 4.1 kg), LIR (subcutaneous administration of 1.2 mg/d, 1.8 mg/d, 2.4 mg/d or 3 mg/d) had an average weight loss of 4.8-7.2 kg, the two-year extended experiment of which also showed similar results (88, 89)