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ISO-induced rats (Group III) enhanced the expression of MMP-2, MMP-9, TGF-, fibronectin, a -SMA, and collagen I when compared to control rats

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One way that insulin resistance affects hormones is by disrupting the function of the hypothalamic-pituitary-adrenal (HPA) axis, which is a complex system that regulates the bodys stress response.In insulin resistance, the body produces more cortisol, a stress hormone that can lead to a range of negative effects, including weight gain, increased appetite, and decreased insulin sensitivity