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SIRT3 expression is downregulated in obese patients, and deletion of SIRT3 leads to increased mitochondrial oxidative stress, reduced energy expenditure and worsened glucose metabolism, resulting in accelerated obesity under a high-fat diet (HFD) feeding [25, 26]

Ozempic (semaglutide) is a prescription drug thats used in people with type 2 diabetes

FIGURE 8 PCs and their metabolites exhibit significant therapeutic potential in the pathogenesis of diabetic nephropathy through multiple mechanisms, including antioxidant and anti-fibrotic effects, as well as the regulation of key signaling pathways

It functions by mimicking the GLP-1 hormone, helping manage blood sugar levels