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Abstract Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for diabetes and obesity, exhibit pleiotropic effectsincluding anti-inflammatory, antioxidant, and neuroprotective propertiesthat position them as transformative candidates for ocular therapeutics

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However, a series of downstream inflammatory pathways activated after ferroptosis cannot be ignored, and these pathways further promote angiogenesis and focal fibrosis (Fig