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The crucial bone-resorbing function of osteoclasts which originate from macrophages, also highlight the significant contribution of innate immune cells to the bone-immune system ( NAC possesses immunomodulatory properties, notably by inhibiting oxidation-sensitive signaling pathways such as NF-B and MAPK (Tieu et al., 2023)

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Phase II data showed up to 24.2% mean body weight reduction at 48 weeks at the highest dose approximately 10 percentage points above semaglutide's best observed outcome

Restrictions apply to the availability of these data, which were used under license for this study