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The STEP trials evaluating semaglutide 2.4 mg for weight management reported gallbladder disorders in approximately 1.6-2.6% of participants receiving the medication versus 0.7-1.2% receiving placebo
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22 Interestingly, UV levels have also been shown to influence activity of the cSHMT enzyme, with a preliminary study observing translation of this enzyme as increased significantly in UV-exposed cells
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