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The European Medicines Agency approves all GLP-1 medications for use down to an eGFR of 15 mL/min/1.73 m , making them viable even in late-stage kidney disease

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Thats why my administration has taken action to strengthen primary care and reduce unnecessary costs and why my FY 2026 budget continues to prioritize investments that improve access, affordability, and quality. Christopher Gavin can be reached at [email protected].

Decision factors: Weight loss goals: Want maximum weight loss and can tolerate side effects: Tirzepatide (Zepbound) shows ~4% greater weight loss than semaglutide on average Want proven cardiovascular benefits: Semaglutide has demonstrated 20% reduction in major cardiovascular events in the SELECT trial Want to try oral option: Oral semaglutide (Rybelsus) for diabetes, though weight loss is less than injectable Side effect sensitivity: Some people tolerate one better than the other