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353 Collectively, these genetic disorders underscore the non-redundant role of the UPS in preventing protein aggregation and preserving neuronal viability

PubMed 11713214 Stier H

Apo(a) is a distinctive protein that resembles plasminogen (the bloods clot-dissolving protein), giving Lp(a) some unique properties

Actually, the reduction in TAC points to an improvement in the status of oxidative stress, as the perturbation in redox homeostasis induces up-regulation of endogenous antioxidant defenses, mediated by activation of redox-sensitive transcription factors and its downstream signaling pathways, causing an increase in the overall capacity to antagonize the harmful effects of oxidative damage (Done and Traustadttir, 2016)