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Increased cell death contributes to the pathophysiology of CD and occurs through non-programmed (i.e., necrosis) and programmed cell death pathways (i.e., apoptosis) [6]

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51,52,62 Qualifying for liver transplantation not only requires a projected poor outcome and high risk of mortality based on these scoring systems but also necessitates a multidisciplinary approach that includes psychiatric evaluation, which may be challenging for patients who have intentionally overdosed on APAP