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Each phase presents different challenges and opportunities
The glucagon receptor arm the feature that distinguishes retatrutide from earlier-generation incretin compounds drives hepatic glucose metabolism, lipid oxidation, and energy expenditure effects, all absent from GLP-1 mono-agonists and dual GLP-1/GIP agonists
Protocol 1: twice weekly split (most common) This is the most widely adopted microdosing approach
Such limitations make it difficult to distinguish true sensory modulation from conditioned aversion secondary to nausea or early satiety effects that are well documented across GLP-1RA trials (153, 157, 173, 180)
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