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Plaintiffs in thousands of lawsuits now pending in federal and state courts allege that the manufacturers of these drugs failed to adequately warn patients and physicians about these severe risks

Annual measurement of B12 levels in those on longterm meformin therapy has been recommended since the 1970's

The limb and tail malformations were consistent with results of animal studies conducted with topiramate alone

They are further graded on a 4-point scale3: In choosing the treatment for hemorrhoids, one should consider the disease grade and severity, its impact on the quality of life, the degree of pain it causes, the patients likelihood of adhering to treatment and the patients personal preference