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This effect is characterized by elevation of glucose secretory response by oral glucose administration in comparison to intravenous administration even though they have similar plasma concentrations

reported that certain types of secondary BAs can activate TGR5, leading to the synthesis of active thyroid hormones in brown adipose tissue and skeletal muscle

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Additionally, the injection products may contain aluminum which may reach toxic concentrations with prolonged administration in patients with impaired renal function or in premature neonates with immature kidneys