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Conversely, GLP-1 receptor agonists inhibit AgRP/NPY neurons through a mechanism involving enhanced presynaptic GABAergic input mediated by both TRPC5 and K_ATP channels, and an indirect suppression of excitatory glutamatergic input via polysynaptic circuits [11]

FDA-Approved Weight Loss Medications Tirzepatide (Mounjaro, Zepbound) Semaglutide (Ozempic, Wegovy, Rybelsus) Stomach paralysis Upper stomach pain Swelling that makes it hard to breathe or swallow Rapid heartbeat If you experience these symptoms, contact your healthcare provider right away

Long-term safety beyond 12 weeks has not been formally studied in large populations

A bariatric pharmacist or specialist clinician can provide individualised advice on medication administration post-surgery