One more thing to consider is whether or not oral GLP-1 agonists obtain FDA approval for obesity
Viral particles like simian virus (SV) 40 and other polyomaviruses 87,88 , and toxins like Shiga and cholera toxin 89,90 , bind to gangliosides like GM1
Heindel JJ, Howard S, Agay-Shay K, Arrebola JP, Audouze K, Babin PJ, Barouki R, Bansal A, Blanc E, Cave MC, Chatterjee S, Chevalier N, Choudhury M, Collier D, Connolly L, Coumoul X, Garruti G, Gilbertson M, Hoepner LA, Holloway AC, Howell G, Kassotis CD, Kay MK, Kim MJ, Lagadic-Gossmann D, Langouet S, Legrand A, Li Z, Le Mentec H, Lind L, Monica Lind P, Lustig RH , Martin-Chouly C, Munic Kos V, Podechard N, Roepke TA, Sargis RM, Starling A, Tomlinson CR, Touma C, Vondracek J, Vom Saal F, Blumberg B
Aescin can alleviate NAFLD through Keap1-Nrf2 by activating antioxidant and autophagy